Regenerative Medicine 2018: Session 9–Reversing brain damage and cognitive dysfunction in professional NFL players

Brain trauma from concussive and subconcussive impacts is frequent in professional American football players. We performed a clinical trial in 100 NFL players measuring the impact of participating in professional football on long term brain function. This was followed by an open label pragmatic clinical intervention in 30 retired NFL players who demonstrated significant global hypoperfusion as measured with neuroimaging in addition to clinical impairments in behavior, mood and cognition. This study included the use of multiple interventions that include dietary modifications, nutrient support, neurofeedback and hyperbaric oxygen therapy. Statistically significant improvements were observed across multiple cognitive domains and enhanced perfusion was present in the prefrontal cortex, parietal lobes, occipital lobes, anterior cingulate gyrus and cerebellum. Finding effective brain rehabilitation strategies serve active and retired players but can be applicable to informing research in the fields of antiaging and regenerative medicine.